New Study: Scientists Link Protein Marker with Mesothelioma Prognosis

Australian researchers say the protein Ki67 can be used to help predict survival in people suffering from malignant peritoneal mesothelioma.

Molecular biologists in New South Wales say a protein linked to cell proliferation could be a powerful prognostic indicator for mesothelioma. Surviving Mesothelioma has just posted an article on the new research.

Doctors at the University of New South Wales tested for Ki67 expression in tissue samples from 42 patients with peritoneal mesothelioma and found a direct correlation with outcomes.

“High expression of Ki67 (≥25% by immunohistochemical evaluation) was correlated with poor survival in the overall group,” reports corresponding author and molecular biologist Krishna Pillai.

According to the article:

A cellular marker that helps tell cancer cells to replicate may be used to predict treatment outcomes in people with malignant peritoneal mesothelioma.

That conclusion comes from a group of researchers at Australia’s University of New South Wales. The researchers tested tissue samples from 42 mesothelioma patients for the presence of Ki67, a protein associated with cell proliferation. According to the authors, Ki67 has been widely used as a prognostic indicator in other types of cancer, but has not been tested in mesothelioma.

The researchers divided the tissue samples into two groups based on their level of Ki67 expression. Those with a Ki67 expression of less than 25% were put in the low category and all samples above that were classified as high. The tissue samples were further divided into the different peritoneal mesothelioma subtypes: epithelioid, sarcomatoid, and biphasic.

“High expression of Ki67 (≥25% by immunohistochemical evaluation) was correlated with poor survival in the overall group,” reports corresponding author and molecular biologist Krishna Pillai in the American Journal of Clinical Oncology. This held true in both male and female mesothelioma patients with the epithelioid subtypes. Independent of Ki67 expression, having the sarcomatoid type of mesothelioma, having a high peritoneal cancer index (a measure of the extent of peritoneal cancer) and being older than 60 were all associated with lower odds of mesothelioma survival.

Read the full article here.

Copyright © Mesothelioma Resource Guide